This first comprehensive application of “Fast-Fail” evaluated the potential of kappa opioid receptor (KOR) antagonism for treating anhedonia with a POM study determining if robust target engagement favorably impacts brain circuitry hypothesized to mediate clinical effects. The NIMH “Fast-Fail” approach seeks to improve too-often misleading early phase drug development methods by incorporating biomarker-based “Proof-of-Mechanism” (POM) testing in Phase-IIa. RSEK contributed to designing the study, provided data quality oversight, and contributed to writing the manuscript.ĭI, SS, GH and KG participated in recruiting subjects, completing all protocol-specified study procedures including data collection with the subjects and contributed to writing the manuscript. HY served as statistician for the study, contributing to study design, carrying out data analysis, and contributing to writing the manuscript. RDW and JNJJr provided oversight for a study site where they led efforts in training and managing study personnel, recruiting subjects, completing all protocol-specified study procedures including data collection with the subjects and contributed to writing the manuscript.ĪS and MS provided oversight for collection and analysis of the MRI data and contributed to writing the manuscript. SJM, SHL, JRC, GS, and WG contributed to designing the study, provided oversight for a study site where they led efforts in training and managing study personnel, recruiting subjects, completing all protocol-specified study procedures including data collection with the subjects and contributed to writing the manuscript. WZP provided critical intellectual input for designing the study and contributed to writing the manuscript.ĭAP provided critical intellectual input for designing the study, provided training, oversight and data analysis for the aspects of the study related to the behavioral tests and co-wrote the manuscript.ĪEW provided training, oversight, and data analysis for the aspects of the study related to the behavioral tests The contents of this site may not be republished, reprinted, rewritten or recirculated without written permission.AUTHOR CONTRIBUTIONSADK designed the study, provided oversight for all aspects of the study, analyzed the data, and wrote the manuscript. We forward your information to a lender you wish to contact so that they may contact you directly.Ĭopyright © 2023 Consumers Unified, LLC DBA ConsumerAffairs. Rather, we display rates from lenders that are licensed or otherwise authorized to work in Vermont. Home Warranty disclosure for New Jersey Residents: The product being offered is a service contract and is separate and distinct from any product or service warranty which may be provided by the home builder or manufacturer.Ĭonsumers Unified, LLC does not take loan or mortgage applications or make credit decisions. THE LENDER MAY BE SUBJECT TO FEDERAL LENDING LAWS. ![]() THE LENDER MAY NOT BE SUBJECT TO ALL VERMONT LENDING LAWS. ![]() ![]() INFORMATION RECEIVED WILL BE SHARED WITH ONE OR MORE THIRD PARTIES IN CONNECTION WITH YOUR LOAN INQUIRY. It is very important to do your own analysis before making any investment based on your own personal circumstances and consult with your own investment, financial, tax and legal advisers.Ĭompany NMLS Consumer Access #2110672 MORTGAGE BROKER ONLY, NOT A MORTGAGE LENDER OR MORTGAGE CORRESPONDENT LENDER Our content is intended to be used for general information purposes only. Companies displayed may pay us to be Authorized or when you click a link, call a number or fill a form on our site. ConsumerAffairs is not a government agency.
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